Open AccessAllogeneic Transplantation of Müller‐Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion
Author(s) -
Becker Silke,
Eastlake Karen,
Jayaram Hari,
Jones Megan F.,
Brown Robert A.,
McLellan Gillian J.,
Charteris David G.,
Khaw Peng T.,
Limb G. Astrid
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0125
Subject(s) - transplantation , retina , retinal , biology , retinal ganglion cell , muller glia , scotopic vision , intrinsically photosensitive retinal ganglion cells , electroretinography , neuroscience , microbiology and biotechnology , photopic vision , giant retinal ganglion cells , stem cell , pathology , medicine , progenitor cell , biochemistry
This study investigated the effect of allogeneic transplantation of feline Müller glia with the ability to differentiate into cells expressing retinal ganglion cell (RGC) markers, following ablation of RGCs by N ‐methyl‐ d ‐aspartate. The results suggest that Müller glia with stem cell characteristics have a neuroprotective ability that promotes partial recovery of impaired RGC function and indicate that cell attachment onto the retina may be necessary for transplanted cells to confer neuroprotection to the retina.