Open AccessInsulin‐Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo
Author(s) -
Agulnick Alan D.,
Ambruzs Dana M.,
Moorman Mark A.,
Bhoumik Anindita,
Cesario Rosemary M.,
Payne Janice K.,
Kelly Jonathan R.,
Haakmeester Carl,
Srijemac Robert,
Wilson Alistair Z.,
Kerr Justin,
Frazier Mauro A.,
Kroon Evert J.,
D'Amour Kevin A.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0079
Subject(s) - embryonic stem cell , stem cell , in vivo , in vitro , microbiology and biotechnology , enteroendocrine cell , endocrine system , insulin , biology , cellular differentiation , endocrinology , genetics , hormone , gene
This paper describes a new protocol for producing insulin‐producing cells in vitro that represents another potential cell source for a diabetes cell therapy. These cells can be loaded into a protective device that is implanted under the skin. The device is designed to protect the cells from immune rejection by the implant recipient. The implant can engraft and respond to glucose by secreting insulin, thus potentially replacing the β cells lost in patients with type 1 diabetes.