Open AccessOral Mucosal Lamina Propria‐Progenitor Cells Exert Antibacterial Properties via the Secretion of Osteoprotegerin and Haptoglobin
Author(s) -
Board-Davies Emma,
Moses Rachael,
Sloan Alastair,
Stephens Phil,
Davies Lindsay C.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0043
Subject(s) - lamina propria , osteoprotegerin , secretion , progenitor cell , haptoglobin , chemistry , medicine , immunology , cancer research , microbiology and biotechnology , biology , pathology , stem cell , epithelium , activator (genetics) , receptor
The antibacterial properties of oral mucosal lamina propria‐progenitor cells (OMLP‐PCs) was investigated. Analysis of OMLP‐PC conditioned media indicated constitutive secretion of osteoprotegerin and haptoglobin, and exposure of bacteria to these factors demonstrated their differential antibacterial properties. OMLP‐PCs offer great potential in the development of novel cell‐ or soluble factor‐based therapies for the treatment of infectious illnesses and chronic wounds.