Open AccessPlacental Mesenchymal Stromal Cells Rescue Ambulation in Ovine Myelomeningocele
Author(s) -
Wang Aijun,
Brown Erin G.,
Lankford Lee,
Keller Benjamin A.,
Pivetti Christopher D.,
Sitkin Nicole A.,
Beattie Michael S.,
Bresnahan Jacqueline C.,
Farmer Diana L.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0296
Subject(s) - mesenchymal stem cell , in utero , fetal surgery , neurotrophic factors , medicine , neuroprotection , cell therapy , fetus , bioinformatics , stem cell , pathology , biology , pregnancy , receptor , genetics
Early gestation human placenta‐derived mesenchymal stromal cells can augment in utero repair of myelomeningocele (MMC). This treatment results in significant and consistent improvement in neurologic function at birth in the rigorous fetal ovine MMC model. These preclinical results in the well‐established fetal ovine model of MMC provide promising early support for translating in utero stem cell therapy for MMC into clinical application for patients.