Open AccessPhosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats
Author(s) -
Morales-Garcia Jose A.,
Alonso-Gil Sandra,
Gil Carmen,
Martinez Ana,
Santos Angel,
Perez-Castillo Ana
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0277
Subject(s) - pars compacta , dopaminergic , substantia nigra , neurogenesis , neuroprotection , neuroscience , dopamine , parkinson's disease , biology , population , medicine , disease , environmental health
The phosphodiesterase 7 inhibitor S14 is able to induce endogenous neuroregenerative processes toward a dopaminergic phenotype. A population of actively dividing cells that give rise to new neurons in the substantia nigra pars compacta of hemiparkinsonian rats after treatment with S14 is described. The data have identified S14 as a novel regulator of dopaminergic neuron generation.