Open AccessFreshly Thawed and Continuously Cultured Human Bone Marrow‐Derived Mesenchymal Stromal Cells Comparably Ameliorate Allergic Airways Inflammation in Immunocompetent Mice
Author(s) -
Cruz Fernanda F.,
Borg Zachary D.,
Goodwin Meagan,
Sokocevic Dino,
Wagner Darcy,
McKenna David H.,
Rocco Patricia R.M.,
Weiss Daniel J.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0268
Subject(s) - mesenchymal stem cell , bone marrow , inflammation , stromal cell , pathology , allergic inflammation , medicine , human bone , immunology , biology , in vitro , biochemistry
This study addressed whether freshly thawed mesenchymal stromal cells (MSCs) are as effective in in vivo settings as those that have been continuously cultured. It also provided further data demonstrating that xenogeneic use of MSCs in immunocompetent mice is as effective as murine MSCs. This information provides further support and direction for potential clinical use of MSCs in patients with severe asthma.