Open AccessCartilage Repair Using Composites of Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells and Hyaluronic Acid Hydrogel in a Minipig Model
Author(s) -
Ha Chul-Won,
Park Yong-Beom,
Chung Jun-Young,
Park Yong-Geun
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0264
Subject(s) - mesenchymal stem cell , chondrogenesis , regeneration (biology) , umbilical cord , hyaline cartilage , cartilage , hyaluronic acid , stem cell , articular cartilage repair , anatomy , biomedical engineering , tissue engineering , pathology , andrology , medicine , articular cartilage , biology , microbiology and biotechnology , osteoarthritis , alternative medicine
The cartilage regeneration potential of human umbilical cord blood‐derived mesenchymal stem cells (hUCB‐MSCs) with a hyaluronic acid (HA) hydrogel composite has shown remarkable results in small animal models. A minipig model was used to confirm the consistent regenerative potential. This evidence of consistent cartilage regeneration using composites of hUCB‐MSCs and HA hydrogel in a large animal model could be a stepping stone to a human clinical trial in the future.