Open AccessCell Therapy Using Human Induced Pluripotent Stem Cell‐Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice
Author(s) -
Toyohara Takafumi,
Mae Shin-Ichi,
Sueta Shin-Ichi,
Inoue Tatsuyuki,
Yamagishi Yukiko,
Kawamoto Tatsuya,
Kasahara Tomoko,
Hoshina Azusa,
Toyoda Taro,
Tanaka Hiromi,
Araoka Toshikazu,
Sato-Otsubo Aiko,
Takahashi Kazutoshi,
Sato Yasunori,
Yamaji Noboru,
Ogawa Seishi,
Yamanaka Shinya,
Osafune Kenji
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0219
Subject(s) - acute kidney injury , progenitor cell , induced pluripotent stem cell , renal stem cell , medicine , transplantation , kidney , stem cell , cell therapy , stem cell therapy , renal ischemia , regenerative medicine , cancer research , reperfusion injury , biology , ischemia , embryonic stem cell , microbiology and biotechnology , biochemistry , gene
A multistep differentiation protocol for inducing human induced pluripotent stem cells (hiPSCs) into OSR1 + SIX2 + renal progenitors capable of reconstituting three‐dimensional proximal renal tubule‐like structures in vitro and in vivo was established. Renal subcapsular transplantation of hiPSC‐derived renal progenitors ameliorated the acute kidney injury in mice induced by ischemia/reperfusion injury, significantly suppressing the elevation of blood urea nitrogen and serum creatinine levels and attenuating histopathological changes.