Open AccessPre‐Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer
Author(s) -
Smith Chris L.,
Chaichana Kaisorn L.,
Lee Young M.,
Lin Benjamin,
Stanko Kevin M.,
O'Donnell Thomas,
Gupta Saksham,
Shah Sagar R.,
Wang Joanne,
Wijesekera Olindi,
Delannoy Michael,
Levchenko Andre,
Quiñones-Hinojosa Alfredo
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0149
Subject(s) - homing (biology) , mesenchymal stem cell , adipose tissue , cancer stem cell , stem cell , microbiology and biotechnology , cancer cell , cancer research , biology , cancer , neuroscience , medicine , endocrinology , ecology
A reproducible, comprehensive, cell culture‐based approach to enhance human adipose mesenchymal stem cell (hAMSC) engraftment to brain tumors was developed. Pre‐exposing hAMSCs to glioma‐conditioned media and the extracellular matrix proteins fibronectin and laminin resulted in significant enhancements of the individual homing steps in vitro. This comprehensive, cell‐conditioning approach provides a novel method to enhance stem cell homing to gliomas and, potentially, other neurological disorders.