Pre‐Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer | Zendy

Smith Chris L. | Zendy; Chaichana Kaisorn L. | Zendy; Lee Young M. | Zendy; Lin Benjamin | Zendy; Stanko Kevin M. | Zendy; O'Donnell Thomas | Zendy; Gupta Saksham | Zendy; Shah Sagar R. | Zendy; Wang Joanne | Zendy; Wijesekera Olindi | Zendy; Delannoy Michael | Zendy; Levchenko Andre | Zendy; Quiñones-Hinojosa Alfredo | Zendy

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Pre‐Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer

Author(s) -

Smith Chris L.,

Chaichana Kaisorn L.,

Lee Young M.,

Lin Benjamin,

Stanko Kevin M.,

O'Donnell Thomas,

Gupta Saksham,

Shah Sagar R.,

Wang Joanne,

Wijesekera Olindi,

Delannoy Michael,

Levchenko Andre,

Quiñones-Hinojosa Alfredo

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0149

Subject(s) - homing (biology) , mesenchymal stem cell , stem cell , cancer stem cell , tropism , extracellular matrix , cancer research , biology , medicine , immunology , microbiology and biotechnology , ecology , virus

A reproducible, comprehensive, cell culture‐based approach to enhance human adipose mesenchymal stem cell (hAMSC) engraftment to brain tumors was developed. Pre‐exposing hAMSCs to glioma‐conditioned media and the extracellular matrix proteins fibronectin and laminin resulted in significant enhancements of the individual homing steps in vitro. This comprehensive, cell‐conditioning approach provides a novel method to enhance stem cell homing to gliomas and, potentially, other neurological disorders.

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