Adipose‐Derived Stromal Cells Promote Allograft Tolerance Induction | Zendy

Davis Thomas A. | Zendy; Anam Khairul | Zendy; Lazdun Yelena | Zendy; Gimble Jeffrey M. | Zendy; Elster Eric A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Adipose‐Derived Stromal Cells Promote Allograft Tolerance Induction

Author(s) -

Davis Thomas A.,

Anam Khairul,

Lazdun Yelena,

Gimble Jeffrey M.,

Elster Eric A.

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0131

Subject(s) - medicine , transplantation , stromal cell , adipose tissue , stem cell , bone marrow , progenitor cell , immunology , cancer research , biology , microbiology and biotechnology

The ability of adipose‐derived stromal/stem cells (ASCs) to facilitate long‐term allograft survival was investigated. ASC and bone marrow cell (BMC) coinfusion with minimal conditioning led to stable lymphoid and myeloid macrochimerism, deletion of alloreactive T cells, expansion of regulatory T cells, and long‐term allograft survival (>200 days). Translational advanced vascular composite allotransplants with ASCs and low‐dose donor BMCs in nonhuman primates can be developed to enhance functional outcomes and eliminate long‐term immunosuppression.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research