Open AccessAdipose‐Derived Stromal Cells Promote Allograft Tolerance Induction
Author(s) -
Davis Thomas A.,
Anam Khairul,
Lazdun Yelena,
Gimble Jeffrey M.,
Elster Eric A.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0131
Subject(s) - medicine , transplantation , stromal cell , adipose tissue , stem cell , bone marrow , progenitor cell , immunology , cancer research , biology , microbiology and biotechnology
The ability of adipose‐derived stromal/stem cells (ASCs) to facilitate long‐term allograft survival was investigated. ASC and bone marrow cell (BMC) coinfusion with minimal conditioning led to stable lymphoid and myeloid macrochimerism, deletion of alloreactive T cells, expansion of regulatory T cells, and long‐term allograft survival (>200 days). Translational advanced vascular composite allotransplants with ASCs and low‐dose donor BMCs in nonhuman primates can be developed to enhance functional outcomes and eliminate long‐term immunosuppression.