Open AccessConcise Review: Animal Substance‐Free Human Embryonic Stem Cells Aiming at Clinical Applications
Author(s) -
Hovatta Outi,
Rodin Sergey,
Antonsson Liselotte,
Tryggvason Karl
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0129
Subject(s) - embryonic stem cell , induced pluripotent stem cell , regenerative medicine , stem cell , biology , infertility , supernumerary , microbiology and biotechnology , bioinformatics , medicine , anatomy , genetics , pregnancy , gene
This review examines clinical applications of animal substance‐free human embryonic stem cells. Following studies on factors regulating pluripotency and differentiation, there are now techniques to establish and effectively expand these cells in animal substance‐free conditions, even from single cells biopsied from eight‐cell stage embryos in chemically defined feeder‐free cultures. Early clinical trials are ongoing.