Open AccessThe Dose‐Effect Safety Profile of Skeletal Muscle Precursor Cell Therapy in a Dog Model of Intrinsic Urinary Sphincter Deficiency
Author(s) -
Williams J. Koudy,
Eckman Delrae,
Dean Ashley,
Moradi Mahmoudreza,
Allickson Julie,
Cline J. Mark,
Yoo James J.,
Atala Anthony
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0114
Subject(s) - skeletal muscle , urology , urinary system , medicine , endocrinology
The dose‐effect safety profile of skeletal muscle precursor cell (skMPC) therapy was tested in a dog model of intrinsic urinary sphincter deficiency. Injection of different doses of skMPCs had no effects on the body weight, blood cell count, or kidney or liver function test results. Urinary sphincter injection of skMPCs resulted in no significant local or systemic pathologic features within the dose range that improves sphincter pressures.