Open AccessMesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function
Author(s) -
Lin Yu-Ling,
Yet Shaw-Fang,
Hsu Yuan-Tong,
Wang Guei-Jane,
Hung Shih-Chieh
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0091
Subject(s) - mesenchymal stem cell , enos , endothelial dysfunction , transplantation , apolipoprotein e , endothelial stem cell , endocrinology , endothelium , nitric oxide , medicine , immunology , chemistry , nitric oxide synthase , pathology , biochemistry , disease , in vitro
The effects of mesenchymal stem cells (MSCs) on endothelial dysfunction and atherosclerosis were investigated in human/mouse endothelial cells treated with oxidized low‐density lipoprotein and in apolipoprotein E‐deficient (apoE −/− ) mice fed a high‐fat diet. MSC transplantation improved endothelial function and plaque formation, and activation of the Akt/endothelial nitric‐oxide synthase pathway in endothelium by interleukin‐8/MIP‐2 is involved in the protective effect of MSCs. The study supports the use and clarifies the mechanism of MSCs for ameliorating atherosclerosis.