Open AccessDefining the Optimal Window for Cranial Transplantation of Human Induced Pluripotent Stem Cell‐Derived Cells to Ameliorate Radiation‐Induced Cognitive Impairment
Author(s) -
Acharya Munjal M.,
Martirosian Vahan,
Christie Lori-Ann,
Riparip Lara,
Strnadel Jan,
Parihar Vipan K.,
Limoli Charles L.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0063
Subject(s) - neural stem cell , stem cell , transplantation , induced pluripotent stem cell , hippocampal formation , embryonic stem cell , hippocampus , neuroscience , biology , medicine , surgery , microbiology and biotechnology , gene , biochemistry
The authors report the beneficial cognitive effects of transplanting induced pluripotent stem cell‐derived human neural stem cells in the irradiated rodent brain and how these cells differentiate and mitigate neuroinflammation throughout multiple hippocampal subfields. Given the absence of efficacious treatment options for the devastating side effects of cranial radiotherapy, stem cell therapy may provide a viable solution for this long‐term mental health problem afflicting cancer survivors.