Open AccessChemokine‐Mediated Robust Augmentation of Liver Engraftment: A Novel Approach
Author(s) -
Joshi Meghnad,
Oltean Mihai,
Patil Pradeep B.,
Hallberg David,
Kleman Marika,
Holgersson Jan,
Olausson Michael,
Sumitran-Holgersson Suchitra
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0053
Subject(s) - cxcr3 , chemokine , biology , transplantation , immunology , cancer research , chemokine receptor , andrology , medicine , inflammation
The objective of this study was to improve repopulation of the liver with human hepatocytes using chemokines. Results showed that the issue of limited engraftment can be overcome using this novel approach. The improved repopulation of transplanted cells is likely a function of the chemokines to mediate cell homing and retention in the injured liver and might be an attractive strategy to augment repopulation of transplanted hepatocytes in vivo.