Open AccessSimvastatin Radiosensitizes Differentiated and Stem‐Like Breast Cancer Cell Lines and Is Associated With Improved Local Control in Inflammatory Breast Cancer Patients Treated With Postmastectomy Radiation
Author(s) -
Lacerda Lara,
Reddy Jay P.,
Liu Diane,
Larson Richard,
Li Li,
Masuda Hiroko,
Brewer Takae,
Debeb Bisrat G.,
Xu Wei,
Hortobágyi Gabriel N.,
Buchholz Thomas A.,
Ueno Naoto T.,
Woodward Wendy A.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0204
Subject(s) - inflammatory breast cancer , medicine , breast cancer , oncology , triple negative breast cancer , cancer , statin , simvastatin , cancer research
The authors studied the radiosensitization of breast cancer stem‐like cells in vitro after treatment with the most commonly used statin, simvastatin, and examined the influence on local control after postmastectomy radiation among inflammatory breast cancer patients taking statins. This work provides new insight on combination regimens for breast cancer treatment and radiosensitization of this clinically radioresistant disease.