Open AccessCrosstalk Between Adrenergic and Toll‐Like Receptors in Human Mesenchymal Stem Cells and Keratinocytes: A Recipe for Impaired Wound Healing
Author(s) -
Dasu Mohan R.,
Ramirez Sandra R.,
La Thi Dinh,
Gorouhi Farzam,
Nguyen Chuong,
Lin Benjamin R.,
Mashburn Chelcy,
Stewart Heather,
Peavy Thomas R.,
Nolta Jan A.,
Isseroff Roslyn R.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0200
Subject(s) - tlr2 , mesenchymal stem cell , wound healing , receptor , bone marrow , microbiology and biotechnology , chemistry , skin repair , stem cell , cancer research , immunology , biology , innate immune system , biochemistry
This study examined the hypothesis that there is crosstalk between the β2‐adrenergic receptor (β2‐AR) and Toll‐like receptor 2 (TLR2) signaling pathways, using epinephrine and macrophage‐activating lipopeptide‐2 to activate ARs and TLR2, respectively, in human bone marrow‐derived mesenchymal stem cells (BM‐MSCs) and neonatal keratinocytes (NHKs). Results indicate a recipe for decreasing cell migration and exacerbating inflammation via novel crosstalk between the adrenergic and Toll‐like receptor pathways in BM‐MSCs and NHKs.