Open AccessHuman Adult White Matter Progenitor Cells Are Multipotent Neuroprogenitors Similar to Adult Hippocampal Progenitors
Author(s) -
Lojewski Xenia,
Hermann Andreas,
Wegner Florian,
Araúzo-Bravo Marcos J.,
Hallmeyer-Elgner Susanne,
Kirsch Matthias,
Schwarz Johannes,
Schöler Hans R.,
Storch Alexander
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0117
Subject(s) - olig2 , neural stem cell , sox2 , nestin , progenitor cell , biology , oligodendrocyte , stem cell , stem cell marker , neurosphere , neurogenesis , hippocampal formation , microbiology and biotechnology , cellular differentiation , neuroscience , adult stem cell , myelin , transcription factor , central nervous system , genetics , gene
Adult neural progenitor cells (aNPC) are a potential autologous cell source for cell replacement in neurologic diseases or for cell‐based gene therapy of neurometabolic diseases. Our data show that white matter aNPC are multipotent neural progenitor cells (NPC) with long‐term expandability similar to NPC from hippocampus, making them a more easily accessible source for possible autologous NPC‐based treatment strategies.