Open AccessMouse Embryonic Stem Cells Established in Physiological‐Glucose Media Express the High K M Glut2 Glucose Transporter Expressed by Normal Embryos
Author(s) -
Jung Jin Hyuk,
Wang Xiao Dan,
Loeken Mary R.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0093
Subject(s) - glut2 , glucose transporter , embryonic stem cell , biology , embryo , microbiology and biotechnology , endocrinology , medicine , andrology , biochemistry , gene , insulin
This study found that an embryonic stem cell (ESC) line derived in media with glucose at physiological levels expressed a functional Glut2 transporter that is expressed by normal embryos, whereas an established ESC line that had been isolated and propagated in high‐glucose media did not. Glut2‐expressing ESCs should be advantageous for the study of metabolic regulation of embryonic development, as well as for transplantation for therapeutic applications.