Open AccessSafety of Human Neural Stem Cell Transplantation in Chronic Spinal Cord Injury
Author(s) -
Piltti Katja M.,
Salazar Desiree L.,
Uchida Nobuko,
Cummings Brian J.,
Anderson Aileen J.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0064
Subject(s) - spinal cord injury , neural stem cell , transplantation , stem cell , medicine , spinal cord , neuroscience , biology , surgery , microbiology and biotechnology
Human central nervous system‐derived neural stem cell (hCNS‐SCns) transplantation in either the subacute or chronic spinal cord injury microenvironment of immunodeficient rats produced a pattern of cell engraftment, migration, and differentiation that is consistent with previous results in immunodeficient mice. hCNS‐SCns transplantation did not result in anatomical or behavioral evidence of neurological pain or other adverse effects.