Open AccessMesenchymal Stromal Cells Mediate Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation by Inhibition of the Th17 Signaling Pathway
Author(s) -
Lathrop Melissa J.,
Brooks Elice M.,
Bonenfant Nick R.,
Sokocevic Dino,
Borg Zachary D.,
Goodwin Meagan,
Loi Roberto,
Cruz Fernanda,
Dunaway Chad W.,
Steele Chad,
Weiss Daniel J.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0061
Subject(s) - mesenchymal stem cell , stromal cell , inflammation , microbiology and biotechnology , aspergillus fumigatus , chemistry , signal transduction , allergic inflammation , immunology , cancer research , biology
The current study extends previous observations of mesenchymal stromal cell (MSC) effects in models of experimentally induced Th2‐mediated eosinophilic allergic airways inflammation to demonstrate potent MSC effects in a mixed model of Th2/Th17 neutrophilic allergic airways inflammation. Although the mechanisms of MSC actions remain unclear, these studies provide a basis for potential clinical application of MSC‐based cell therapy approaches for patients with severe neutrophilic steroid‐resistant asthma.