Open AccessConcise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?
Author(s) -
Corre Jill,
Hébraud Benjamin,
Bourin Philippe
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0055
Subject(s) - gdf15 , pathological , transforming growth factor , biology , receptor , mechanism (biology) , signal transduction , bioinformatics , immunology , pathology , medicine , microbiology and biotechnology , endocrinology , genetics , philosophy , epistemology
Increased blood concentration of GDF15 is associated with numerous pathological conditions, but the biological significance underlying these observations is far from clear. GDF15 seems to be an integrative signal in pathologic conditions, giving information on severity of disease, but its effectiveness in classifying patients to modulate treatment remains to be shown. This review article surveys the state of current knowledge about GDF15.