Open AccessHoming of Neural Stem Cells From the Venous Compartment Into a Brain Infarct Does Not Involve Conventional Interactions With Vascular Endothelium
Author(s) -
Goncharova Valentina,
Das Shreyasi,
Niles Walter,
Schraufstatter Ingrid,
Wong Aaron K.,
Povaly Tatiana,
Wakeman Dustin,
Miller Leonard,
Snyder Evan Y.,
Khaldoyanidi Sophia K.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0052
Subject(s) - homing (biology) , fucosylation , neural stem cell , endothelium , biology , stem cell , microbiology and biotechnology , immunology , fucose , biochemistry , endocrinology , ecology , glycoprotein
Human neural stem cells (hNSCs) hold great potential for treatment of a wide variety of neurodegenerative and neurotraumatic conditions. However, the findings of this study suggest that the behavior of hNSCs in circulation is different from that observed with other cell types and suggests that, at least for stroke, intravenous administration is a suboptimal route even when the in vitro rolling ability of hNSCs is optimized by enforced fucosylation.