Open AccessIsolation of Neural Progenitor Cells From the Human Adult Subventricular Zone Based on Expression of the Cell Surface Marker CD271
Author(s) -
van Strien Miriam E.,
Sluijs Jacqueline A.,
Reynolds Brent A.,
Steindler Dennis A.,
Aronica Eleonora,
Hol Elly M.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0038
Subject(s) - subventricular zone , neurogenesis , neural stem cell , neurosphere , progenitor cell , biology , neuroscience , glial fibrillary acidic protein , microbiology and biotechnology , stem cell , cellular differentiation , adult stem cell , immunology , immunohistochemistry , biochemistry , gene
A method was developed to specifically isolate neural progenitor cells (NPCs) from postmortem adult human brains based on the expression of the specific human adult neural stem/progenitor cell marker glial fibrillary acidic protein δ. This study shows that a pure population of NPCs can be isolated from the adult human subventricular zone (SVZ), which is highly instrumental for developing future therapies based on stimulating endogenous SVZ neurogenesis.