Open AccessActivation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)‐10 and IL‐1RN Levels
Author(s) -
Bustos Martha L.,
Huleihel Luai,
Meyer Ernest M.,
Donnenberg Albert D.,
Donnenberg Vera S.,
Sciurba Joseph D.,
Mroz Lyle,
McVerry Bryan J.,
Ellis Bryon M.,
Kaminski Naftali,
Rojas Mauricio
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0033
Subject(s) - ards , mesenchymal stem cell , medicine , bronchoalveolar lavage , bone marrow , inflammation , lung , progenitor cell , pulmonary edema , interleukin 1 receptor antagonist , immunology , stem cell , cancer research , pathology , receptor antagonist , receptor , biology , antagonist , microbiology and biotechnology
The objective of this study was to improve the protective anti‐inflammatory capacity of human mesenchymal stem cells (hMSCs) by evaluating the consequences of preactivating them before use in a murine model of acute respiratory distress syndrome. It was found that the immunomodulatory capacity was better in hMSCs obtained with minimal manipulation, showing that it is possible to improve the protective anti‐inflammatory capacity of hMSCs.