Open AccessPlastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System
Author(s) -
Kim Haesun A.,
Mindos Thomas,
Parkinson David B.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0011
Subject(s) - schwann cell , peripheral nervous system , biology , sox2 , neuroscience , regeneration (biology) , microbiology and biotechnology , nervous system , neuroregeneration , nerve injury , kinase , transcription factor , central nervous system , genetics , gene
Repair in the peripheral nervous system (PNS) is a complex process that requires the active de‐differentiation of Schwann cells to an immature repair state following injury; this de‐differentiation is dependent upon the activity of the p38 and ERK1/2 mitogen‐activated protein kinases, as well as the transcription factor cJun. Understanding the mechanisms of repair raises the possibility of both boosting repair after PNS trauma and even, possibly, blocking the inappropriate demyelination seen in some disorders of the peripheral nervous system.