Open AccessBlood Cell‐Derived Induced Pluripotent Stem Cells Free of Reprogramming Factors Generated by Sendai Viral Vectors
Author(s) -
Ye Lin,
Muench Marcus O.,
Fusaki Noemi,
Beyer Ashley I.,
Wang Jiaming,
Qi Zhongxia,
Yu Jingwei,
Kan Yuet Wai
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0006
Subject(s) - induced pluripotent stem cell , sendai virus , reprogramming , biology , stem cell , cd34 , regenerative medicine , induced stem cells , microbiology and biotechnology , embryoid body , haematopoiesis , embryonic stem cell , immunology , cell , genetics , virus , gene
This study demonstrated a reproducible protocol for reprogramming blood cells into transgene‐free induced pluripotent stem cells (iPSCs) using Sendai viral vectors. Creation of iPSCs, without integration of exogenous DNA, helps preserve genomic integrity and fosters the development of therapeutic‐grade stem cells for regenerative medicine.