Open AccessImmunosuppressants Affect Human Neural Stem Cells In Vitro but Not in an In Vivo Model of Spinal Cord Injury
Author(s) -
Sontag Christopher J.,
Nguyen Hal X.,
Kamei Noriko,
Uchida Nobuko,
Anderson Aileen J.,
Cummings Brian J.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0175
Subject(s) - neural stem cell , spinal cord injury , sirolimus , transplantation , stem cell , pi3k/akt/mtor pathway , in vivo , neurosphere , biology , cancer research , immunology , pharmacology , medicine , in vitro , microbiology and biotechnology , spinal cord , signal transduction , adult stem cell , neuroscience , endothelial stem cell , biochemistry
This study investigated whether immunosuppressants can exert direct effects on the differentiation, proliferation, survival, and migration of human central nervous system‐derived stem cells propagated as neurospheres (hCNS‐SCns) in vitro and in an in vivo model of spinal cord injury. Findings suggest that the proliferation, differentiation, and disease‐modifying activity of hCNS‐SCns would be retained in an allogeneic translational setting using clinical immunosuppression protocols.