Open AccessThree Years After Transplants in Human Mandibles, Histological and In‐Line Holotomography Revealed That Stem Cells Regenerated a Compact Rather Than a Spongy Bone: Biological and Clinical Implications
Author(s) -
Giuliani Alessandra,
Manescu Adrian,
Langer Max,
Rustichelli Franco,
Desiderio Vincenzo,
Paino Francesca,
De Rosa Alfredo,
Laino Luigi,
d'Aquino Riccardo,
Tirino Virginia,
Papaccio Gianpaolo
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0136
Subject(s) - biomedical engineering , dental alveolus , materials science , mesenchymal stem cell , mandible (arthropod mouthpart) , stem cell , histology , bone tissue , bone grafting , dentistry , pathology , anatomy , medicine , biology , microbiology and biotechnology , botany , genus
The stability and quality of regenerated bone and vessel network was assessed 3 years after grafting intervention, with conventional procedures and in‐line holotomography. The regenerated tissue from the graft sites was found to be composed of a fully compact bone with a higher matrix density than control human alveolar spongy bone from the same patient. Although the bone regenerated at the graft sites is not of the proper type found in the mandible, it creates steadier mandibles, may well increase implant stability, and, additionally, may improve resistance to mechanical, physical, chemical, and pharmacological agents.