Open AccessA Novel Combinatorial Therapy With Pulp Stem Cells and Granulocyte Colony‐Stimulating Factor for Total Pulp Regeneration
Author(s) -
Iohara Koichiro,
Murakami Masashi,
Takeuchi Norio,
Osako Yohei,
Ito Masataka,
Ishizaka Ryo,
Utunomiya Shinji,
Nakamura Hiroshi,
Matsushita Kenji,
Nakashima Misako
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0132
Subject(s) - dental pulp stem cells , stem cell , pulp (tooth) , transplantation , neurite , biology , microbiology and biotechnology , medicine , pathology , surgery , in vitro , biochemistry
Autologous transplantation of pulp stem cells with granulocyte‐colony stimulating factor (G‐CSF) in a dog pulpectomized tooth yielded better effects than transplantation of G‐CSF or pulp stem cells alone. The combinatorial trophic effects of pulp stem cells and G‐CSF are of immediate utility for pulp/dentin regeneration, demonstrating the prerequisites of safety and efficacy critical for clinical applications.