Open AccessStem Cell Therapy to Cure Type 1 Diabetes: From Hype to Hope
Author(s) -
Chhabra Preeti,
Brayman Kenneth L.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0116
Subject(s) - stem cell , induced pluripotent stem cell , medicine , regenerative medicine , mesenchymal stem cell , stem cell therapy , immunology , cell therapy , clinical uses of mesenchymal stem cells , adult stem cell , transplantation , autoimmunity , embryonic stem cell , biology , cancer research , immune system , microbiology and biotechnology , pathology , biochemistry , gene
This study examines the therapeutic potential of stem cells derived from a variety of sources for the cure of type 1 diabetes mellitus, for example, embryonic stem cells, induced pluripotent stem cells, bone marrow‐derived hematopoietic stem cells, and multipotent mesenchymal stromal cells derived from bone marrow, umbilical cord blood, and adipose tissue. The benefits of combinatorial approaches designed to ensure the successful clinical translation of stem cell therapeutic strategies, such as approaches combining effective stem cell strategies with islet transplantation, immunomodulatory drug regimens, and/or novel bioengineering techniques, are also discussed.