Open AccessIntegration and Regression of Implanted Engineered Human Vascular Networks During Deep Wound Healing
Author(s) -
Hanjaya-Putra Donny,
Shen Yu-I,
Wilson Abigail,
Fox-Talbot Karen,
Khetan Sudhir,
Burdick Jason A.,
Steenbergen Charles,
Gerecht Sharon
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0111
Subject(s) - wound healing , regeneration (biology) , transplantation , inflammation , angiogenesis , hyaluronic acid , tissue engineering , medicine , progenitor cell , stem cell , pathology , biomedical engineering , anatomy , microbiology and biotechnology , surgery , biology , immunology , cancer research
This study assessed the functionality and durability of engineered human vasculatures from endothelial progenitors when implanted in a mouse deep burn‐wound model. Human vascular networks, derived from endothelial colony‐forming cells in hyaluronic acid hydrogels, were transplanted into third‐degree burns. Collectively, the findings suggest that human vasculature engineered from endothelial colony‐forming cells can integrate with the host vessels in a deep third‐degree burn model and that hyaluronic acid hydrogels that support the precise formation of human vasculature in vitro can be successfully delivered to the site of injury, where they can survive and integrate with the host vasculature.