Open AccessReprogramming of Fibroblasts From Older Women With Pelvic Floor Disorders Alters Cellular Behavior Associated With Donor Age
Author(s) -
Wen Yan,
Wani Prachi,
Zhou Lu,
Baer Tom,
Phadnis Smruti Madan,
Reijo Pera Renee A.,
Chen Bertha
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0092
Subject(s) - reprogramming , pelvic floor disorders , pelvic floor , ageing , medicine , gerontology , biology , anatomy , cell , genetics
The effect of donor age on induced pluripotent stem cell (iPSC) lines and on the cells redifferentiated from these iPSCs was examined. iPSCs were derived from vaginal fibroblasts from women with pelvic organ prolapse. Donor age did not appear to affect reprogramming and cell mitotic activity in fibroblasts redifferentiated from iPSCs, and donor age differences were not observed in the iPSCs using standard senescence markers.