Open AccessTransient Brown Adipocyte‐Like Cells Derive from Peripheral Nerve Progenitors in Response to Bone Morphogenetic Protein 2
Author(s) -
Salisbury Elizabeth A.,
Lazard ZaWaunyka W.,
Ubogu Eroboghene E.,
Davis Alan R.,
Olmsted-Davis Elizabeth A.
Publication year - 2012
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0090
Subject(s) - bone morphogenetic protein 2 , microbiology and biotechnology , progenitor cell , biology , sciatic nerve , adipose tissue , bone morphogenetic protein , stem cell , medicine , anatomy , endocrinology , biochemistry , gene , in vitro
It has been found that cells residing in the perineurium of adult mouse peripheral nerves expand and undergo brown adipocyte differentiation in response to bone morphogenetic protein 2 (BMP2). These perineurial cells, which normally reside in the adult nerve and express beta‐3 adrenergic receptor, undergo replication and migration following neurogenic inflammation. Blocking this inflammatory remodeling completely suppresses the formation of brown adipocytes through this mechanism. This is the first report that progenitors of brown adipose may reside in the perineurium of peripheral nerves in adult mice.