Open AccessElevated Nuclear Factor Erythroid‐2 Levels Promote Epo‐Independent Erythroid Maturation and Recapitulate the Hematopoietic Stem Cell and Common Myeloid Progenitor Expansion Observed in Polycythemia Vera Patients
Author(s) -
Bogeska Ruzhica,
Pahl Heike L.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0046
Subject(s) - stem cell factor , haematopoiesis , stem cell , cd34 , polycythemia vera , myeloid , progenitor cell , biology , cancer research , erythropoietin , transcription factor , immunology , hematopoietic stem cell , microbiology and biotechnology , endocrinology , genetics , gene
The transcription factor nuclear factor erythroid‐2 (NF‐E2) is overexpressed in the majority of polycythemia vera (PV) patients. In this study, elevation of NF‐E2 expression in healthy CD34 + cells to levels observed in PV caused Epo‐independent erythroid maturation and expansion of hematopoietic stem cell (HSC) and common myeloid progenitor (CMP) cell numbers. Silencing NF‐E2 in PV patients reverted both aberrancies, demonstrating for the first time that NF‐E2 overexpression is both required and sufficient for Epo independence and HSC/CMP expansion in PV.