Open AccessIntranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma
Author(s) -
Reitz Matthias,
Demestre Maria,
Sedlacik Jan,
Meissner Hildegard,
Fiehler Jens,
Kim Seung U.,
Westphal Manfred,
Schmidt Nils Ole
Publication year - 2012
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2012-0045
Subject(s) - progenitor cell , glioma , neural stem cell , stem cell , nasal administration , medicine , transplantation , u87 , cancer research , pathology , biology , immunology , microbiology and biotechnology
This study investigates the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as an alternative, noninvasive, and direct passage for the delivery of stem cells to target intracerebral pathologies such as malignant gliomas. Intranasal administration offers the possibility of multiple treatments potentially using tumor‐targeting NSPCs with different therapeutic payloads during the disease course.