Open AccessMultipotent Stromal Stem Cells from Human Placenta Demonstrate High Therapeutic Potential
Author(s) -
Nazarov Igor,
Lee Jae W.,
Soupene Eric,
Etemad Sara,
Knapik Derrick,
Green William,
Bashkirova Elizaveta,
Fang Xiaohui,
Matthay Michael A.,
Kuypers Frans A.,
Serikov Vladimir B.
Publication year - 2012
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2011-0021
Subject(s) - stem cell , amniotic epithelial cells , homeobox protein nanog , amniotic stem cells , microbiology and biotechnology , biology , mesenchymal stem cell , multipotent stem cell , adult stem cell , germ layer , stem cell transplantation for articular cartilage repair , embryonic stem cell , stromal cell , cellular differentiation , immunology , cancer research , endothelial stem cell , progenitor cell , induced pluripotent stem cell , in vitro , genetics , gene
This study describes human chorionic mesenchymal stem cell (hCMSC) lines obtained from the chorion of human term placenta with high therapeutic potential in human organ pathology. In vitro, hCMSCs could be differentiated into derivatives of all three germ layers, and it was demonstrated ex vivo that they effectively facilitated repair of injured epithelium. It is concluded that the chorion of human term placenta is an abundant source of multipotent stem cells that are promising candidates for cell‐based therapies.