Open AccessGenome Mining of EndophyticStreptomyces wadayamensisReveals High Antibiotic Production Capability
Author(s) -
Célio Fernando Figueiredo Angolini,
Ana B. Gonçalves,
Renata Sigrist,
Bruno S. Paulo,
Markiyan Samborskyy,
Pedro L. R. Cruz,
Adriana F. Vivian,
Eduardo Morgado Schmidt,
Marcos N. Eberlin,
Welington Luiz Araújo,
Luciana G. de Oliveira
Publication year - 2016
Publication title -
journal of the brazilian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.337
H-Index - 70
eISSN - 1678-4790
pISSN - 0103-5053
DOI - 10.5935/0103-5053.20160180
Subject(s) - actinobacteria , strain (injury) , streptomyces , genome , antibiotics , biology , genetics , computational biology , gene , microbiology and biotechnology , bacteria , 16s ribosomal rna , anatomy
The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics.
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