Grinding and Milling: Two Efficient Methodologies in the Solvent-Free Phosphomolybdic Acid-Catalyzed and Mechanochemical Synthesis ofcis-4-Amido-N-yl-2-methyl-tetrahydroquinolines | Zendy

Vladímir V. Kouznetsov | Zendy; Diego R. Merchán-Arenas | Zendy; Carlos A. Martínez Bonilla | Zendy; Mario A. Macías | Zendy; Pascal Roussel | Zendy; Gilles H. Gauthier | Zendy

Open Access

Grinding and Milling: Two Efficient Methodologies in the Solvent-Free Phosphomolybdic Acid-Catalyzed and Mechanochemical Synthesis ofcis-4-Amido-N-yl-2-methyl-tetrahydroquinolines

Author(s) -

Vladímir V. Kouznetsov,

Diego R. Merchán-Arenas,

Carlos A. Martínez Bonilla,

Mario A. Macías,

Pascal Roussel,

Gilles H. Gauthier

Publication year - 2016

Publication title -

journal of the brazilian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.337

H-Index - 70

eISSN - 1678-4790

pISSN - 0103-5053

DOI - 10.5935/0103-5053.20160117

Subject(s) - phosphomolybdic acid , catalysis , chemistry , ball mill , grinding , solvent , organic chemistry , raw material , chemical engineering , materials science , metallurgy , engineering

The ball-milling process of ABB' Povarov reaction through mechano-chemical activation with phosphomolybdic acid (PMA) as heteropolyacid (HPA) catalyst, was first time explored. The developed high speed vibratory ball milling (HSVBM) green method offers simple and efficient diastereoselective synthesis of cis-2,4-disubstituted tetrahydroquinolines in good to excellent yields (56-76%).

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