New Epimeric Spirostanol and Furostanol-Type Steroidal Saponins fromCestrum laevigatumL. | Zendy

Paulo Riceli Vasconcelos Ribeiro | Zendy; Raimundo BrazFilho | Zendy; Ana Jérsia Araújo | Zendy; Letícia V. CostaLotufo | Zendy; Luciana G. S. Souza | Zendy; Hélio Vitoriano Nobre Júnior | Zendy; Cecília Rocha da Silva | Zendy; João Batista de Andrade Neto | Zendy; Edilberto R. Silveira | Zendy; Mary Anne Sousa Lima | Zendy

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New Epimeric Spirostanol and Furostanol-Type Steroidal Saponins fromCestrum laevigatumL.

Author(s) -

Paulo Riceli Vasconcelos Ribeiro,

Raimundo BrazFilho,

Ana Jérsia Araújo,

Letícia V. CostaLotufo,

Luciana G. S. Souza,

Hélio Vitoriano Nobre Júnior,

Cecília Rocha da Silva,

João Batista de Andrade Neto,

Edilberto R. Silveira,

Mary Anne Sousa Lima

Publication year - 2016

Publication title -

journal of the brazilian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.337

H-Index - 70

eISSN - 1678-4790

pISSN - 0103-5053

DOI - 10.5935/0103-5053.20160109

Subject(s) - chemistry

Four new epimeric spirostanol and furostanol-type steroidal saponins, (25R,S)-5α-spirostan2α,3β-diol 3-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-galactopyranoside, (25R,S)-5α-spirostan-2α,3β-diol 3-O-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→4)β-D-galactopyranoside, 26-O-β-D-glucopyranosyl-(25R,S)-5α-furost-20-ene,2α,3β-diol 3-O-β-Dgalactopyranoside and 26-O-β-D-glucopyranosyl-(25R,S)-5α-furost-20-ene,2α,3β-diol 3-O-β-Dgalactopyranosyl-(1→4)-β-D-galactopyranoside, in addition to the known (25R,S)-5α-spirostan2α,3β-diol 3-O-β-D-galactopyranoside, were isolated from Cestrum laevigatum. Compounds were submitted to cytotoxic activity assays using colorectal adenocarcinoma (HCT-116), human promyelocytic leukemia (HL-60), ovarian carcinoma (OVCAR-8), glioma (SF-295) human cancer cell lines, and the antimicrobial activity was evaluated against Candida parapsilosis, C. albicans, C. krusei, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis.

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