SELECTIVE DETECTION OF FLUORIDE BASED ON A PYRIDINIUMN-PHENOLATE-CALIX[4]PYRROLE DISPLACEMENT ASSAY: AN UNDERGRADUATE LABORATORY EXPERIMENT | Zendy

Karina Mannrich | Zendy; Marcelo Silva | Zendy; Leandro G. Nandi | Zendy; Celso R. Nicoleti | Zendy; Vanderlei G. Machado | Zendy

Open Access

SELECTIVE DETECTION OF FLUORIDE BASED ON A PYRIDINIUMN-PHENOLATE-CALIX[4]PYRROLE DISPLACEMENT ASSAY: AN UNDERGRADUATE LABORATORY EXPERIMENT

Author(s) -

Karina Mannrich,

Marcelo Silva,

Leandro G. Nandi,

Celso R. Nicoleti,

Vanderlei G. Machado

Publication year - 2014

Publication title -

química nova

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.214

H-Index - 73

eISSN - 1678-7064

pISSN - 0100-4042

DOI - 10.5935/0100-4042.20140249

Subject(s) - pyridinium , fluoride , pyrrole , chemistry , displacement (psychology) , combinatorial chemistry , nuclear chemistry , chromatography , medicinal chemistry , inorganic chemistry , organic chemistry , psychology , psychotherapist

A two-step experiment is proposed for a third year class in experimental organic chemistry. Over a period of five weeks, the students synthesized calix[4]pyrrole, a receptor that is highly selective for fluoride, and a pyridinium N-phenolate dye. Subsequently, the students used the synthesized compounds to investigate a displacement assay on the basis of the competition in acetonitrile between fluoride and the dye for calix[4]pyrrole. The experiment increased the students' skills in organic synthesis and in the characterization of organic compounds, provided a very attractive and accessible illustration of important supramolecular phenomena, and allowed the study of a chromogenic chemosensor

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