Open AccessSYNTHESIS AND EVALUATION OF OCTOCRYLENE-INSPIRED COMPOUNDS FOR UV-FILTER ACTIVITY
Author(s) -
Hudson Polonini,
Rosângela da Silva Lopes,
Adilson Beatriz,
Roberto da Silva Gomes,
Adriano O. Silva,
Ricardo Vieira Lima,
Gláucia. A. Nunes,
Marcos Antônio Fernandes Brandão,
Nádia Rezende Barbosa Raposo,
Dênis Pires de Lima
Publication year - 2014
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20140160
Subject(s) - sunscreening agents , chemistry , uv filter , computer science , biochemical engineering , environmental science , physics , optics , medicine , engineering , cancer , skin cancer
Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) ranging from 1 to 8. Compounds 4, 5, and 7 showed the best protection against UVB sunrays, while compounds 5, 6, and 7 presented the best results for protection from UVA, so compound 7 had the most balanced protection overall. Results for compounds 4, 8, and 9 are reported for the first time in the literature
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