Open AccessTRANSDERMAL FORMULATIONS CONTAINING HUMAN SEXUAL STEROIDS: DEVELOPMENT AND VALIDATION OF METHODS ANDIN VITRODRUG RELEASE
Author(s) -
Hudson Polonini,
Pedro Paulo Soldati,
Marcone Augusto Leal de Oliveira,
Marcos Antônio Fernandes Brandão,
Maria das Graças M. Chaves,
Nádia Rezende Barbosa Raposo
Publication year - 2014
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.5935/0100-4042.20140116
Subject(s) - transdermal , pharmacology , drug , in vitro , transdermal patch , chemistry , medicine , chromatography , biochemistry
In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. For this purpose, novel high-performance liquid chromatography methods were developed and validated in an eco-friendly manner and used to determine the in vitro release of such products. The methods were suitable for our intended goal, and the emulsions employed were found to be effective as transporting candidates for the efficient release of hormones in the transdermal delivery of human sexual steroids
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