Catechins as antidiabetic compounds of Bridelia ferruginea Benth root bark extract | Zendy

Batomayena Bakoma | Zendy; Berke Benedicte | Zendy; Aboudoulatif Diallo | Zendy; Kwashie Eklu-Gadégbéku | Zendy; Aklikokou Kodjo | Zendy; Messanvi Gbeassor | Zendy; Moore Nicholas | Zendy

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Catechins as antidiabetic compounds of Bridelia ferruginea Benth root bark extract

Author(s) -

Batomayena Bakoma,

Berke Benedicte,

Aboudoulatif Diallo,

Kwashie Eklu-Gadégbéku,

Aklikokou Kodjo,

Messanvi Gbeassor,

Moore Nicholas

Publication year - 2018

Publication title -

journal of pharmacognosy and phytotherapy

Language(s) - English

Resource type - Journals

ISSN - 2141-2502

DOI - 10.5897/jpp2018.0528

Subject(s) - streptozotocin , diabetes mellitus , traditional medicine , bark (sound) , chemistry , hyperlipidemia , pharmacology , medicine , endocrinology , biology , ecology

The present study was carried out to evaluate the antidiabetic activity of catechins isolated from Bridelia ferruginea in previous studies. Epigallocatechin (EGC) and Epigallocatechin gallate (EGCG) isolated from B. ferruginea were administrated to streptozotocin-induced diabetic mice to evaluate their anti-hyperglycemic and anti-hyperlipidemic effects. Then, biochemical parameters were assayed in different groups of streptozotocin-induced diabetic mice. The level of fasting blood glucose levels, triglycerides (TG) and total cholesterol (TC) in streptozotocin-induced diabetic mice were significantly decreased after daily oral administration of EGC and EGCG at doses of 10 mg/kg/day, for 21 days. Glucose intolerance was significantly reduced in streptozotocin induced diabetic mice treated with catechins. These results suggest that catechins constituents from B. ferruginea, revealed significant anti-hyperglycemic and antihyperlipidemic activity in type 2 diabetes. Key words: Bridelia ferruginea, epigallocatechin, streptozotocin, diabetes, medicinal plant.

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