Acute toxicity evaluation of ethanol extract of red algae, Osmundaria obtusiloba, in BALB/c mice | Zendy

Caroline de Souza Barros | Zendy; Willian Lisboa Gomes Max | Zendy; dos Santos Pereira Gomes Rafaela | Zendy; Melchiades Vanessa | Zendy; Cesar Richter Nogueira Caio | Zendy; César Cirne-Santos Claudio | Zendy; Garrido Valeria | Zendy; Carla Eponina Carvalho-Pinto | Zendy; Laneuville Teixeira Valéria | Zendy; Christiunes de Palmer Paixão Izabel | Zendy

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Acute toxicity evaluation of ethanol extract of red algae, Osmundaria obtusiloba, in BALB/c mice

Author(s) -

Caroline de Souza Barros,

Willian Lisboa Gomes Max,

dos Santos Pereira Gomes Rafaela,

Melchiades Vanessa,

Cesar Richter Nogueira Caio,

César Cirne-Santos Claudio,

Garrido Valeria,

Carla Eponina Carvalho-Pinto,

Laneuville Teixeira Valéria,

Christiunes de Palmer Paixão Izabel

Publication year - 2018

Publication title -

journal of medicinal plants research

Language(s) - English

Resource type - Journals

ISSN - 1996-0875

DOI - 10.5897/jmpr2018.6582

Subject(s) - acute toxicity , toxicity , biology , ethanol , algae , toxicology , traditional medicine , botany , chemistry , medicine , biochemistry , organic chemistry

The genus Osmundaria (Rhodophyta, Ceramilaes, Rhodomelaceae) comprises tropical and temperate regions red marine seaweeds species. Osmundaria obtusiloba is distributed from the northeastern coast of Brazil to the state of Rio de Janeiro. Studies with ethanol extract of red seaweed O. obtusiloba showed the antiviral potential of this alga. Hence, this study examined in BALB/c mice the acute toxicity after oral administration of O. obtusiloba crude extract. Then, female BALB/c mice received a single dose of O. obtusiloba extract by gavage at 550 mg/kg and their behaviors were monitored for a 14 day period. The biochemical and histological changes in the liver, kidney, stomach and spleen were analyzed. O. obtusiloba extract did not significantly change behavior, body weight, hematological or biochemical profiles. The organs of the animals did not show significant alterations when submitted to treatment with O. obtusiloba extract. In conclusion, the in vivo results revealed that O. obtusiloba has low toxicity and it can be and may be the target of further studies of biological activity. Key words: Osmundaria obtusiloba; acute toxicity; seaweeds; preclinical tests.

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