In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses | Zendy

A. Padilla Marina | Zendy; C. Simoni Isabela | Zendy; Moreira H. Hoe Veronica | Zendy; Judite Bittencourt Fernandes Maria | Zendy; W. Arns Clarice | Zendy; Juliana R. Brito | Zendy; Henrique G. Lago João | Zendy

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In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses

Author(s) -

A. Padilla Marina,

C. Simoni Isabela,

Moreira H. Hoe Veronica,

Judite Bittencourt Fernandes Maria,

W. Arns Clarice,

Juliana R. Brito,

Henrique G. Lago João

Publication year - 2018

Publication title -

journal of medicinal plants research

Language(s) - English

Resource type - Journals

ISSN - 1996-0875

DOI - 10.5897/jmpr2018.6567

Subject(s) - gallic acid , quercetin , traditional medicine , biology , population , biochemistry , medicine , antioxidant , environmental health

The Brazilian savanna known as “Cerrado” is very rich in medicinal plants that are used by the local population for treatment of several illnesses. The herpesvirus is a serious problem worldwide, and affects both animal and human health. This work aimed to study the antiviral activity of eight extracts from plants natives of “Cerrado” region against human (HSV-1), equine (EqHV-1) and swine herpesviruses (SuHV-1). The results showed that all plant extracts: Banisteriopsis variabilis, Byrsonima intermedia, Campomanesia xanthocarpa, Erythroxilum deciduum, Lacistema hasslerianum, Ocotea pulchella, Stryphodendron adstringens and Xylopia aromatica presented antiviral activity against at least one herpesvirus. Furthermore, it was observed a direct anti-herpes effect of extracts from B. variabilis and B. intermedia in non-toxic concentrations against all herpesviruses. B. intermedia crude aqueous extract showed the most promising results with selective index values of the 41.76 ± 0.04; 4.12 ± 0.1 and 193.97 ± 0.09 respectively against HSV-1, EqHV-1 and SuHV-1. Due to this, B. intermedia extract was also analyzed by HPLC/MS allowing for the identification of gallic acid and quercetin as main compounds. Key words: Brazilian savanna, Cerrado, Byrsonima intermedia, antiviral, herpesvirus, gallic acid, quercetin.

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