A new pterocarpan from the leaves of Abrus precatorius L. | Zendy

Namuga Catherine | Zendy; C. Caroline | Zendy; N Guantai Anastasia | Zendy; C Chhabra Sumesh | Zendy

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A new pterocarpan from the leaves of Abrus precatorius L.

Author(s) -

Namuga Catherine,

C. Caroline,

N Guantai Anastasia,

C Chhabra Sumesh

Publication year - 2015

Publication title -

journal of medicinal plants research

Language(s) - English

Resource type - Journals

ISSN - 1996-0875

DOI - 10.5897/jmpr2015.5787

Subject(s) - abrus precatorius , artemia salina , brine shrimp , dept , chemistry , heteronuclear molecule , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , dichloromethane , traditional medicine , nuclear magnetic resonance spectroscopy , biology , botany , biochemistry , organic chemistry , toxicity , medicine , solvent

A pterocarpan, 2,3,4,8-tetramethoxy-6a,11a-dihydro-6H-benzo[4,5]furo[3,2-c]chromene-7,9-diol (compound 1) was isolated from the dichloromethane extract of the leaves of Abrus precatorius L. The structure of the compound was elucidated by detailed spectroscopic analysis such as 1H NMR, 13C NMR, Distortionless Enhancement by Polarisation Transfer (DEPT), Heteronuclear Multiple-Quantum Correlation (HMQC) and Heteronuclear Multiple-Bond Correlation (HMBC). The crude extracts displayed brine shrimp lethality and in vitro antimalarial activity. The methanolic crude extract demonstrated a A/B ratio of 9.7 signifying that it is more toxic against Plasmodium falciparum than brine shrimp. Key words: Fabaceae, Papilionaceae, Abrus precatorius, pterocarpan, brine shrimp lethality, antiplasmodial activity.

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