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The antimicrobial effect of the leaf extract and fractions of Lupinus arboreus was investigated. The crude methanol extract (CME) of the dried leaves obtained by 48 h cold maceration was fractionated into n-hexane fraction (HEF), ethyl acetate fraction (EAF), and methanol fraction (MEF); and evaluated using modified agar-well diffusion method. The results showed that the extract and fractions at varying concentrations, exerted strong antimicrobial activity on some of the test organisms. However, a weak activity was observed on the tested fungi-Aspergillus niger and Candida albicans. Ethyl acetate fraction showed the highest activity on many organisms than extract and other fractions.   Key words: Lupinus arboreus, antimicrobial activity, standard drugs, test organisms, extracts and fractions.

Antimicrobial activity of the leaf extract and fractions of Lupinus arboreus