-Glucosidase inhibitory potential of selected anti-diabetic plants used in North-Western Nigeria | Zendy

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-Glucosidase inhibitory potential of selected anti-diabetic plants used in North-Western Nigeria

Author(s) -

Onu,

rew,

Yusuf Saidu,

Muktar Jangabe Ladan,

Suleman Lawal Bilbis,

Aliyu Adamu Aliero

Publication year - 2013

Publication title -

journal of medicinal plants research

Language(s) - English

Resource type - Journals

ISSN - 1996-0875

DOI - 10.5897/jmpr12.1005

Subject(s) - mangifera , chemistry , traditional medicine , alpha glucosidase , glycoside , acarbose , bark (sound) , botany , stereochemistry , biology , biochemistry , medicine , enzyme , ecology

α-Glucosidase inhibitory potential of selected anti-diabetic plants has been studied. The study evaluated α-glucosidase inhibition using α-glucosidase from Saccharomyces cerevisiae and p-nitrophenyl α-D-glucopyranoside as substrate. The result showed that the extract of Albizzia chevalieri leaf, Khaya senegalensis stem bark, Zizypus spina-christistem bark, Arachis hypogea seed varieties and Mangifera indica leaf had significant (P < 0.05) α-glucosidase inhibitory effect in a concentration dependant manner as compared to acarbose. Cardiac glycosides, alkaloids, saponins, flavonoids and tannins were identified in the extracts. The study concludes that the plant extract contain bioactive compound that may be source(s) of lead compounds with α-glucosidase inhibitory potentials and may explain their hypoglycaemic effects. Key words: Postprandial hyperglycaemia, α-glucosidase inhibitor, antidiabetic plants, hypoglycaemic potential.

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