Antimicrobial activity and phytochemical screening of various parts of Ixora coccinea | Zendy

M Mani | Zendy; Arul Aruldass Claira | Zendy; Mageswary Sandrasagaran Uma | Zendy; Suriyati Mohamad | Zendy; Surash Ramanathan | Zendy; Mahsufi Mansor Sharif | Zendy; Murugaiyah Vikneswaran | Zendy

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Antimicrobial activity and phytochemical screening of various parts of Ixora coccinea

Author(s) -

M Mani,

Arul Aruldass Claira,

Mageswary Sandrasagaran Uma,

Suriyati Mohamad,

Surash Ramanathan,

Mahsufi Mansor Sharif,

Murugaiyah Vikneswaran

Publication year - 2014

Publication title -

journal of medicinal plants research

Language(s) - English

Resource type - Journals

ISSN - 1996-0875

DOI - 10.5897/jmpr11.1281

Subject(s) - antimicrobial , phytochemical , minimum inhibitory concentration , traditional medicine , terpenoid , minimum bactericidal concentration , flavonoid , agar diffusion test , chemistry , biology , staphylococcus aureus , botany , microbiology and biotechnology , bacteria , medicine , biochemistry , genetics , antioxidant

Ixora coccinea L. (Rubiaceae) has been used traditionally for a variety of ailments and also cultivated for ornamental purposes. The present study investigated antimicrobial activity of methanolic extracts of various parts of I. coccinea and determined the chemical groups of the active constituents. Antimicrobial activity was assessed using agar disc diffusion, microdilution and thin layer chromatography (TLC) bioautography assays. Methanolic extracts of leaf, flower and stem of I. coccinea displayed good antimicrobial activity, with inhibition zone in the range of 6.7 to 11.3 mm. minimum inhibitory concentration (MIC) values for all three extracts ranged from 0.78 to 3.125 mg/ml. Leaf and stem extracts of I. coccinea showed broad-spectrum antimicrobial activity. Of interest, stem extracts had MIC values against Staphylococcus aureus that were only 62.4 times less potent than the vancomycin. Likewise, leaf and stem extracts displayed good antimicrobial activity of 62.4 and 31.2 times, respectively lesser than gentamycin against Shigella flexneri. Minimum bactericidal/ bacteriostatic concentration (MBC) values for active extracts ranged from 0.78 to 6.25 mg/ml. TLC bioautography and phytochemical screening of the leaf and stem extracts showed that the antimicrobial activity of these extracts may be attributed to compounds belonging to terpenoid, flavonoid, coumarin, alkaloid and phenolic groups. Key words: Antimicrobial, Ixora coccinea, minimum inhibitory concentration, minimum bacteriostatic/bacteriocidal concentration, bioautography.

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